Functional characterization of agonists at recombinant human 5‐HT2A, 5‐HT2B and 5‐HT2C receptors in CHO‐K1 cells

H. Porter, Richard; Benwell, Karen; Lamb, Helen; Malcolm, C; H. Allen, Nicola; F. Revell, Dean; R. Adams, David; J. Sheardown, Malcolm

doi:10.1038/sj.bjp.0702751

Public

Functional characterization of agonists at recombinant human 5‐HT2A, 5‐HT2B and 5‐HT2C receptors in CHO‐K1 cells

Published in British Journal of Pharmacology • Sep 1, 1999

Authors:

Richard H. Porter

Karen Benwell

Helen Lamb

Abstract

1. The goal of this study was to characterize the agonist pharmacology of human 5-HT2A, 5-HT2B and 5-HT2C (VSV) receptors expressed in CHO-K1 (Chinese hamster ovary) cells. 2. We used a fluorometric imaging plate reader (FLIPR) which allows rapid detection of rises in intracellular calcium levels up...

Subject

Chinese hamster ovary cell

Agonist

Receptor

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