Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism

M. Sureban, Sripathi; May, Randal; Mondalek, Fadee; Qu, Dongfeng; Ponnurangam, Sivapriya; Pantazis, Panayotis; Anant, Shrikant; P. Ramanujam, Rama; W. Houchen, Courtney

doi:10.1186/1477-3155-9-40

Public

Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism

Published in Journal of Nanobiotechnology • Sep 19, 2011

Authors:

Sripathi M. Sureban

Randal May

Fadee Mondalek

Abstract

BACKGROUND: The development of effective drug delivery systems capable of transporting small interfering RNA (siRNA) has been elusive. We have previously reported that colorectal cancer tumor xenograft growth was arrested following treatment with liposomal preparation of siDCAMKL-1. In this report, ...

Subject

Gene knockdown

Downregulation and upregulation

Small interfering RNA

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