Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis

Gillet, Ludovic; Navarro, Pedro; Tate, Stephen; Röst, Hannes; Selevsek, Nathalie; Reiter, Lukas; F. Bonner, R.; Aebersold, Ruedi

doi:10.1074/mcp.o111.016717

Public

Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis

Published in Molecular & Cellular Proteomics • Jan 19, 2012

Authors:

Ludovic Gillet

Pedro Navarro

Stephen Tate

Abstract

Most proteomic studies use liquid chromatography coupled to tandem mass spectrometry to identify and quantify the peptides generated by the proteolysis of a biological sample. However, with the current methods it remains challenging to rapidly, consistently, reproducibly, accurately, and sensitively...

Subject

Proteome

Computational biology

Mass spectrometry

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