Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging

Akerboom, Jasper; Chen, Tsai‐Wen; J. Wardill, Trevor; Tian, Lin; S. Marvin, Jonathan; Mutlu, Sevinç; Carreras Calderón, Nicole; Esposti, Federico; G. Borghuis, Bart; Richard Sun, Xiaonan; Gordus, Andrew; B. Orger, Michael; Portugues, Rubén; Engert, Florian; J. Macklin, J.; Filosa, Alessandro; Aggarwal, Aman; Kerr, Rex; Takagi, Ryousuke; Kracun, Sebastian; Shigetomi, Eiji; S. Khakh, Baljit; Baier, Herwig; Lagnado, Leon; S.‐H. Wang, Samuel; I. Bargmann, Cornelia; E. Kimmel, Bruce; Jayaraman, Vivek; Svoboda, Karel; S. Kim, Douglas; R. Schreiter, Eric; L. Looger, Loren

doi:10.1523/jneurosci.2601-12.2012

Public

Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging

Published in Journal of Neuroscience • Oct 3, 2012

Authors:

Jasper Akerboom

Tsai‐Wen Chen

Trevor J. Wardill

Abstract

Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience. Recent efforts in protein engineering have significantly increased the performance of GECIs. The state-of-the art single-wavelength GECI, GCaMP3, has been deployed in a number of model organisms and can relia...

Subject

Neuroscience

Calcium imaging

Optogenetics

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