Role of TNF-alpha in sensitization of nociceptive dorsal horn neurons induced by application of nucleus pulposus to L5 dorsal root ganglion in rats

J. Cuellar, M; P. Montesano, X; Carstens, E.

doi:10.1016/j.pain.2004.03.029

Public

Role of TNF-alpha in sensitization of nociceptive dorsal horn neurons induced by application of nucleus pulposus to L5 dorsal root ganglion in rats

Published in Pain • May 8, 2004

Authors:

M J. Cuellar

X P. Montesano

E. Carstens

Abstract

Herniation of the nucleus pulposus (NP) from lumbar intervertebral discs commonly results in radiculopathic pain and paresthesia (sciatica). While traditionally considered the result of mechanical compression of the dorsal root ganglion (DRG) and/or spinal nerve root, recent studies implicate pro-in...

Subject

Dorsal root ganglion

Dorsum

Sensitization

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