Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.

Zhao, Jian; Wu, Hui; Khosravi, Melanie; Cui, Huijuan; Qian, Xiaoxia; A Kelly, Jennifer; M Kaufman, Kenneth; D Langefeld, Carl; H Williams, Adrienne; E Comeau, Mary; T Ziegler, Julie; C Marion, Miranda; Adler, Adam; B Glenn, Stuart; E Alarcón-Riquelme, Marta; Network, BIOLUPUS; Network, GENLES; A Pons-Estel, Bernardo; B Harley, John; Bae, Sang-Cheol; Bang, So-Young; Cho, Soo-Kyung; O Jacob, Chaim; J Vyse, Timothy; B Niewold, Timothy; M Gaffney, Patrick; L Moser, Kathy; P Kimberly, Robert; C Edberg, Jeffrey; E Brown, Elizabeth; S Alarcon, Graciela; A Petri, Michelle; Ramsey-Goldman, Rosalind; M Vilá, Luis; D Reveille, John; A James, Judith; S Gilkeson, Gary; L Kamen, Diane; I Freedman, Barry; Anaya, Juan-Manuel; T Merrill, Joan; A Criswell, Lindsey; Hal Scofield, R; M Stevens, Anne; M Guthridge, Joel; Chang, Deh-Ming; Wook Song, Yeong; Ah Park, Ji; Young Lee, Eun; A Boackle, Susan

doi:10.1371/journal.pgen.1002079

Public

Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.

Shared by NobleBlocks on May 1, 2011 • 12:00 AM UTC

Authors:

Jian Zhao

Hui Wu

Melanie Khosravi

Abstract

Systemic lupus erythematosus (SLE), a complex polygenic autoimmune disease, is associated with increased complement activation. Variants of genes encoding complement regulator factor H (CFH) and five CFH-related proteins (CFHR1-CFHR5) within the chromosome 1q32 locus linked to SLE, have been associa...

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