Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal

M. Carlin, Leo; G. Stamatiades, Efstathios; Auffray, Cédric; N. Hanna, Richard; Glover, Leanne; Vizcay‐Barrena, Gema; C. Hedrick, Catherine; Terence Cook, H.; S. Diebold, Sandra; Geissmann, Frédéric

doi:10.1016/j.cell.2013.03.010

Public

Nr4a1-Dependent Ly6Clow Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal

Published in Cell • Apr 1, 2013

Authors:

Leo M. Carlin

Efstathios G. Stamatiades

Cédric Auffray

Abstract

The functions of Nr4a1-dependent Ly6C(low) monocytes remain enigmatic. We show that they are enriched within capillaries and scavenge microparticles from their lumenal side in a steady state. In the kidney cortex, perturbation of homeostasis by a TLR7-dependent nucleic acid "danger" signal, which ma...

Subject

Biology

Cell biology

Monocyte

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