Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells.

Ramirez, Jean-Marie; C Brembilla, Nicolò; Sorg, Olivier; Chicheportiche, Rachel; Matthes, Thomas; Dayer, Jean-Michel; Saurat, Jean-Hilaire; Roosnek, Eddy; Chizzolini, Carlo

doi:10.1002/eji.201040461

Public

Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells.

Shared by NobleBlocks on Sep 1, 2010 • 12:00 AM UTC

Authors:

Jean-Marie Ramirez

Nicolò C Brembilla

Olivier Sorg

Abstract

Ligands of the aryl hydrocarbon receptor (AHR), a transcription factor mediating the effects of dioxin, favor Th17 differentiation and exacerbate autoimmunity in mice. We investigated how AHR ligands affected human T-cell polarization. We found that the high affinity and stable AHR-ligand dioxin as ...

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