Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL‐22 and IL‐17 production by human T helper cells

Ramirez, Jean‐Marie; Costantino Brembilla, Nicolò; Sorg, Olivier; Chicheportiche, Rachel; Matthes, Thomas; Dayer, Jean‐Michel; Saurat, Jean‐Hilaire; Roosnek, Eddy; Chizzolini, Carlo

doi:10.1002/eji.201040461

Public

Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL‐22 and IL‐17 production by human T helper cells

Published in European Journal of Immunology • Jul 13, 2010

Authors:

Jean‐Marie Ramirez

Nicolò Costantino Brembilla

Olivier Sorg

Abstract

Ligands of the aryl hydrocarbon receptor (AHR), a transcription factor mediating the effects of dioxin, favor Th17 differentiation and exacerbate autoimmunity in mice. We investigated how AHR ligands affected human T-cell polarization. We found that the high affinity and stable AHR-ligand dioxin as ...

Subject

Aryl hydrocarbon receptor

RAR-related orphan receptor gamma

Orphan receptor

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