Optimal Design of a Single Recombinant Adeno-associated Virus Derived from Serotypes 1 and 2 to Achieve More Tightly Regulated Transgene Expression from Nonhuman Primate Muscle

Chenuaud, Pierre; Larcher, Thibaut; E. Rabinowitz, Joseph; Provost, Nathalie; Joussemet, Béatrice; Bujard, Hermann; Jude Samulski, R.; Moullier, Philippe; Favre, David

doi:10.1016/j.ymthe.2003.12.015

Public

Optimal Design of a Single Recombinant Adeno-associated Virus Derived from Serotypes 1 and 2 to Achieve More Tightly Regulated Transgene Expression from Nonhuman Primate Muscle

Published in Molecular Therapy • Feb 11, 2004

Authors:

Pierre Chenuaud

Thibaut Larcher

Joseph E. Rabinowitz

Abstract

Recombinant adeno-associated virus (rAAV) vector supports long-term transgene expression from skeletal muscle in most mammals, including human. In some instances, the requirement for tight control of the transgene expression is expected. The original tetracycline-dependent system using the rtTA (Dox...

Subject

Biology

Transgene

Woodchuck hepatitis virus

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