Programmed Death of T Cells in HIV-1 Infection

Meyaard, Linde; A. Otto, Sigrid; R. Jonker, Richard; Janneke Mijnster, M.; Keet, René; Miedema, Frank

doi:10.1126/science.1352911

Public

Programmed Death of T Cells in HIV-1 Infection

Published in Science • Jul 10, 1992

Authors:

Linde Meyaard

Sigrid A. Otto

Richard R. Jonker

Abstract

In human immunodeficiency virus (HIV) infection, functional defects and deletion of antigen-reactive T cells are more frequent than can be explained by direct viral infection. On culturing, both CD4+ and CD8+ T cells from asymptomatic HIV-infected individuals died as a result of programmed cell deat...

Subject

Programmed cell death

Apoptosis

Human immunodeficiency virus (HIV)

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