Homozygous Human TAP Peptide Transporter Mutation in HLA Class I Deficiency

de la Salle, Henri; Hanau, Daniel; Fricker, Dominique; Urlacher, A.; P. Kelly, Adrian; Salamero, Jean; H. Powis, Stephen; Donato, Lionel; Bausinger, Huguette; Laforet, M.; Jeras, Matjaž; Spehner, Danièle; Bieber, Thomas; Falkenrodt, A.; Cazenave, Jean‐Pierre; Trowsdale, John; Tongio, Marie‐Marthe

doi:10.1126/science.7517574

Public

Homozygous Human TAP Peptide Transporter Mutation in HLA Class I Deficiency

Published in Science • Jul 8, 1994

Authors:

Henri de la Salle

Daniel Hanau

Dominique Fricker

Abstract

Human lymphocyte antigen (HLA) class I proteins of the major histocompatibility complex are largely dependent for expression on small peptides supplied to them by transporter associated with antigen processing (TAP) protein. An inherited human deficiency in the TAP transporter was identified in two ...

Subject

Human leukocyte antigen

Mutation

Transporter

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