Clustering of α 5 β 1 integrins determines adhesion strength whereas α v β 3 and talin enable mechanotransduction

Roca‐Cusachs, Pere; C. Gauthier, Nils; E. del Río Hernández, Armando; P. Sheetz, Michael

doi:10.1073/pnas.0902818106

Public

Clustering of α 5 β 1 integrins determines adhesion strength whereas α v β 3 and talin enable mechanotransduction

Published in Proceedings of the National Academy of Sciences • Sep 3, 2009

Authors:

Pere Roca‐Cusachs

Nils C. Gauthier

Armando E. del Río Hernández

Abstract

A key molecular link between cells and the extracellular matrix is the binding between fibronectin and integrins alpha(5)beta(1) and alpha(v)beta(3). However, the roles of these different integrins in establishing adhesion remain unclear. We tested the adhesion strength of fibronectin-integrin-cytos...

Subject

Integrin

Fibronectin

Mechanotransduction

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