The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation.

D, Dobrev; A, Friedrich; N, Voigt; N, Jost; E, Wettwer; T, Christ; M, Knaut; U, Ravens

doi:10.1161/circulationaha.105.575332

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The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation.

Shared by NobleBlocks on Dec 5, 2005 • 12:00 AM UTC

Authors:

Dobrev D

Friedrich A

Voigt N

Abstract

Background The molecular mechanism of increased background inward rectifier current (IK1) in atrial fibrillation (AF) is not fully understood. We tested whether constitutively active acetylcholine (ACh)-activated I(K,ACh) contributes to enhanced basal conductance in chronic AF (cAF).Methods and resu...

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