Impaired IRS-1/PI3-kinase signaling in patients with HCV: a mechanism for increased prevalence of type 2 diabetes.

S, Aytug; D, Reich; LE, Sapiro; D, Bernstein; N, Begum

doi:10.1016/j.hep.2003.09.012

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Impaired IRS-1/PI3-kinase signaling in patients with HCV: a mechanism for increased prevalence of type 2 diabetes.

Shared by NobleBlocks on Dec 1, 2003 • 12:00 AM UTC

Authors:

Aytug S

Reich D

Sapiro LE

Abstract

Patients with hepatitis C virus (HCV) infection have a greater risk of developing type 2 diabetes mellitus. However, the mechanism of this association is unclear. In this study, we examined the potential defects in upstream insulin signaling pathways in liver specimens obtained from nonobese/nondiab...

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