A NOVEL IMMUNOSUPPRESSANT, FTY720, WITH A UNIQUE MECHANISM OF ACTION, INDUCES LONG-TERM GRAFT ACCEPTANCE IN RAT AND DOG ALLOTRANSPLANTATION1

Suzuki, Seiichi; Enosawa, Shin; Kakefuda, Toshihiro; Shinomiya, Takahisa; Amari, Masao; Naoe, Shiro; Hoshino, Yukio; Chiba, Kenji

doi:10.1097/00007890-199601270-00006

Public

A NOVEL IMMUNOSUPPRESSANT, FTY720, WITH A UNIQUE MECHANISM OF ACTION, INDUCES LONG-TERM GRAFT ACCEPTANCE IN RAT AND DOG ALLOTRANSPLANTATION1

Published in Transplantation • Jan 1, 1996

Authors:

Seiichi Suzuki

Shin Enosawa

Toshihiro Kakefuda

Abstract

A new compound with an immunosuppressive property was purified from culture filtrates of Isaria sinclairii and was chemically modified to FTY720. Rat spleen cells incubated with FTY720 demonstrated features characteristic of apoptosis--such as the absence of surface microvilli, chromatin condensatio...

Subject

Allotransplantation

Apoptosis

Pharmacology

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