Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia

J. Lee, Patty; Jiang, Bing‐Hua; Yoke Chin, Beek; V. Iyer, Narayan; Alam, Jawed; L. Semenza, Gregg; Choi, AugustineM.K.

doi:10.1074/jbc.272.9.5375

Public

Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia

Published in Journal of Biological Chemistry • Feb 1, 1997

Authors:

Patty J. Lee

Bing‐Hua Jiang

Beek Yoke Chin

Abstract

Exposure of rats to hypoxia (7% O2) markedly increased the level of heme oxygenase-1 (HO-1) mRNA in several tissues. Accumulation of HO-1 transcripts was also observed after exposure of rat aortic vascular smooth muscle (VSM) cells to 1% O2, and this induction was dependent on gene transcription. Ac...

Subject

Heme oxygenase

Molecular biology

Chloramphenicol acetyltransferase

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