CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity

A. Fehniger, Todd; A. Cooper, Megan; J. Nuovo, Gerard; Cella, Marina; Facchetti, Fabio; Colonna, Marco; A. Caligiuri, Michael

doi:10.1182/blood-2002-09-2876

Public

CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity

Published in Blood • Apr 2, 2003

Authors:

Todd A. Fehniger

Megan A. Cooper

Gerard J. Nuovo

Abstract

Natural killer (NK) cells are innate lymphocytes that provide cytokines critical for early host defense against pathogens. One subset of human NK cells (CD56(bright)) constitutively expresses the high-affinity interleukin 2 (IL-2) receptor and produces immunoregulatory cytokines. Here, we demonstrat...

Subject

Biology

Acquired immune system

Innate immune system

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