Association of the <i>APC</i> Gene Product with β-Catenin

Rubinfeld, Bonnee; Souza, Brian; Albert, Iris; Müller, Oliver; Chamberlain, Scott; R. Masiarz, Frank; Munemitsu, S; Polakis, Paul

doi:10.1126/science.8259518

Public

Association of the APC Gene Product with β-Catenin

Published in Science • Dec 10, 1993

Authors:

Bonnee Rubinfeld

Brian Souza

Iris Albert

Abstract

Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and gastric tumors. To gain insight into APC function, APC-associated proteins were identified by immunoprecipitation experiments. Antibodies to APC precipitated a 95-kilodalton...

Subject

Adenomatous polyposis coli

Immunoprecipitation

Catenin

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!