Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System

Kishimoto, Takashi; Viswanathan, Karthik; Ganguly, Tanmoy; Elankumaran, Subbiah; G. Smith, Sean; D. Pelzer, Kevin; C. Lansing, Jonathan; Sriranganathan, Nammalwar; Zhao, Ganlin; Galcheva-Gargova, Zoya; Al‐Hakim, Ali; Scott Bailey, Gregory; A. Fraser, Blair; Roy, Sucharita; Rogers-Cotrone, Thomas; F. Buhse, Lucinda; T. Whary, Mark; G. Fox, James; Nasr, Moheb; J. Dal Pan, Gerald; Shriver, Zachary; Langer, Róbert; Venkataraman, Ganesh; Frank Austen, K.; Woodcock, Janet; Sasisekharan, Ram

doi:10.1056/nejmoa0803200

Public

Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System

Published in New England Journal of Medicine • Apr 23, 2008

Authors:

Takashi Kishimoto

Karthik Viswanathan

Tanmoy Ganguly

Abstract

BACKGROUND: There is an urgent need to determine whether oversulfated chondroitin sulfate (OSCS), a compound contaminating heparin supplies worldwide, is the cause of the severe anaphylactoid reactions that have occurred after intravenous heparin administration in the United States and Germany. METH...

Subject

Heparin

Medicine

Complement system

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