Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus Vaccines

Züst, Roland; Cervantes‐Barragán, Luisa; Kuri, Thomas; Blakqori, Gjon; Weber, Friedemann; Ludewig, Burkhard; Thiel, Volker

doi:10.1371/journal.ppat.0030109

Public

Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus Vaccines

Published in PLoS Pathogens • Aug 8, 2007

Authors:

Roland Züst

Luisa Cervantes‐Barragán

Thomas Kuri

Abstract

Attenuated viral vaccines can be generated by targeting essential pathogenicity factors. We report here the rational design of an attenuated recombinant coronavirus vaccine based on a deletion in the coding sequence of the non-structural protein 1 (nsp1). In cell culture, nsp1 of mouse hepatitis vir...

Subject

Mouse hepatitis virus

Virology

Biology

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