Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation

Janbon, Guilhem; L. Ormerod, Kate; Paulet, Damien; J. Byrnes, Edmond; Yadav, Vikas; Chatterjee, Gautam; Mullapudi, Nandita; Hon, Chung-Chau; Blake Billmyre, R.; Brunel, François; Bahn, Yong‐Sun; Chen, Weidong; Chen, Yuan; W. L. Chow, Eve; Coppée, Jean‐Yves; Floyd-Averette, Anna; Gaillardin, Claude; J. Gerik, Kimberly; M. Goldberg, Jonathan; Gonzalez-Hilarion, Sara; Gujja, Sharvari; L. Hamlin, Joyce; Hsueh, Yen‐Ping; Ianiri, Giuseppe; J.M. Jones, Steven; D. Kodira, Chinnappa; Kozubowski, Lukasz; C. Lam, Woei; A. Marra, Marco; D. Mesner, Larry; A. Mieczkowski, Piotr; Moyrand, Frédérique; Nielsen, Kirsten; Proux, Caroline; Rossignol, Tristan; E. Schein, Jacqueline; Sun, Sheng; Wollschlaeger, Carolin; Wood, Ian; Zeng, Qiandong; Neuvéglise, Cécile; S. Newlon, Carol; R. Perfect, John; K. Lodge, Jennifer; Idnurm, Alexander; Stajich, Jason; W. Kronstad, James; Sanyal, Kaustuv; Heitman, Joseph; A. Fraser, James; A. Cuomo, Christina; S. Dietrich, Fred

doi:10.1371/journal.pgen.1004261

Public

Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation

Published in PLoS Genetics • Apr 17, 2014

Authors:

Guilhem Janbon

Kate L. Ormerod

Damien Paulet

Abstract

Cryptococcus neoformans is a pathogenic basidiomycetous yeast responsible for more than 600,000 deaths each year. It occurs as two serotypes (A and D) representing two varieties (i.e. grubii and neoformans, respectively). Here, we sequenced the genome and performed an RNA-Seq-based analysis of the C...

Subject

Biology

Genetics

Cryptococcus neoformans

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