Phase II clinical trial of Wilms tumor 1 peptide vaccination for patients with recurrent glioblastoma multiforme

Izumoto, Shuichi; Tsuboi, Akihiro; Oka, Yoshitaka; Suzuki, Tsuyoshi; Hashiba, Tetsuo; Kagawa, Naoki; Hashimoto, Naoya; Maruno, Motohiko; A. Elisseeva, Olga; Shirakata, Toshiaki; Kawakami, Manabu; Oji, Yusuke; Nishida, Sumiyuki; Ohno, Satoshi; Kawase, Ichiro; Hatazawa, Jun; Nakatsuka, Shin‐ichi; Aozasa, Katsuyuki; Morita, Satoshi; Sakamoto, Junichi; Sugiyama, Haruo; Yoshimine, Toshiki

doi:10.3171/jns/2008/108/5/0963

Public

Phase II clinical trial of Wilms tumor 1 peptide vaccination for patients with recurrent glioblastoma multiforme

Published in Journal of neurosurgery • Apr 30, 2008

Authors:

Shuichi Izumoto

Akihiro Tsuboi

Yoshitaka Oka

Abstract

OBJECT: The object of this study was to investigate the safety and clinical responses of immunotherapy targeting the WT1 (Wilms tumor 1) gene product in patients with recurrent glioblastoma multiforme (GBM). METHODS: Twenty-one patients with WT1/HLA-A*2402-positive recurrent GBM were included in a P...

Subject

Medicine

Progressive disease

Wilms' tumor

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