A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin

Liao, Longyan; Liu, Jenny; C. Dreaden, Erik; W. Morton, Stephen; E. Shopsowitz, Kevin; T. Hammond, Paula; A. Johnson, Jeremiah

doi:10.1021/ja502011g

Public

A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin

Published in Journal of the American Chemical Society • Apr 11, 2014

Authors:

Longyan Liao

Jenny Liu

Erik C. Dreaden

Abstract

The synthesis of polymer therapeutics capable of controlled loading and synchronized release of multiple therapeutic agents remains a formidable challenge in drug delivery and synthetic polymer chemistry. Herein, we report the synthesis of polymer nanoparticles (NPs) that carry precise molar ratios ...

Subject

Camptothecin

Chemistry

Doxorubicin

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