Intracisternal delivery of AAV9 results in oligodendrocyte and motor neuron transduction in the whole central nervous system of cats

Bücher, Thomas; Dubreil, Laurence; Colle, M-A; Maquigneau, Maud; Deniaud, Johan; Ledevin, Mireille; Moullier, Philippe; Joussemet, Béatrice

doi:10.1038/gt.2014.16

Public

Intracisternal delivery of AAV9 results in oligodendrocyte and motor neuron transduction in the whole central nervous system of cats

Published in Gene Therapy • Feb 27, 2014

Authors:

Thomas Bücher

Laurence Dubreil

M-A Colle

Abstract

Systemic and intracerebrospinal fluid delivery of adeno-associated virus serotype 9 (AAV9) has been shown to achieve widespread gene delivery to the central nervous system (CNS). However, after systemic injection, the neurotropism of the vector has been reported to vary according to age at injection...

Subject

Tropism

Cisterna magna

Spinal cord

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!