Identification of Human Plasma Lysophospholipase D, a Lysophosphatidic Acid-producing Enzyme, as Autotaxin, a Multifunctional Phosphodiesterase

Tokumura, Akira; Majima, Eiji; Kariya, Yuko; Tominaga, Kyoko; Kogure, Kentaro; Yasuda, Katsuhiko; Fukuzawa, Kenji

doi:10.1074/jbc.m205623200

Public

Identification of Human Plasma Lysophospholipase D, a Lysophosphatidic Acid-producing Enzyme, as Autotaxin, a Multifunctional Phosphodiesterase

Published in Journal of Biological Chemistry • Oct 1, 2002

Authors:

Akira Tokumura

Eiji Majima

Yuko Kariya

Abstract

We purified human plasma lysophospholipase D that produces physiologically active lysophosphatidic acid and showed that it is a soluble form of autotaxin, an ecto-nucleotide pyrophosphatase/phosphodiesterase, originally found as a tumor cell motility-stimulating factor. Its lower K(m) value for a ly...

Subject

Autotaxin

Lysophosphatidic acid

Lysophosphatidylcholine

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