Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

B. Selenica, Maj-Linda; L. Brownlow, Milene; P. Jimenez, Jeffy; C. Lee, Daniel; Peña, Gabriela; A. Dickey, Chad; N. Gordon, Marcia; Morgan, Dave

doi:10.1159/000337230

Public

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

Published in Neurodegenerative Diseases • Jul 10, 2012

Authors:

Maj-Linda B. Selenica

Milene L. Brownlow

Jeffy P. Jimenez

Abstract

BACKGROUND: We aimed to investigate the influence of oligomeric forms of β-amyloid (Aβ) and the influence of the duration of exposure on the development of tau phosphorylation. METHODS: Aβ oligomers were injected intracranially either acutely into 5-month-old rTg4510 mice and tissue was collected 3 ...

Subject

Tauopathy

Genetically modified mouse

Tangle

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