Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy.

B Selenica, Maj-Linda; Brownlow, Milene; P Jimenez, Jeffy; C Lee, Daniel; Pena, Gabriela; A Dickey, Chad; N Gordon, Marcia; Morgan, Dave

doi:10.1159/000337230

Public

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy.

Shared by NobleBlocks on Jan 1, 2013 • 12:00 AM UTC

Authors:

Maj-Linda B Selenica

Milene Brownlow

Jeffy P Jimenez

Abstract

BACKGROUND: We aimed to investigate the influence of oligomeric forms of β-amyloid (Aβ) and the influence of the duration of exposure on the development of tau phosphorylation. METHODS: Aβ oligomers were injected intracranially either acutely into 5-month-old rTg4510 mice and tissue was collected 3 ...

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