The Role of Phospholipase A2 and Nitric Oxide in Pain-Related Behavior Produced by an Allograft of Intervertebral Disc Material to the Sciatic Nerve of the Rat

Kawakami, Mamoru; Tamaki, Tetsuya; Hashizume, Hiroshi; N. Weinstein, James; T. Meller, Stephen

doi:10.1097/00007632-199705150-00004

Public

The Role of Phospholipase A2 and Nitric Oxide in Pain-Related Behavior Produced by an Allograft of Intervertebral Disc Material to the Sciatic Nerve of the Rat

Published in Spine • May 1, 1997

Authors:

Mamoru Kawakami

Tetsuya Tamaki

Hiroshi Hashizume

Abstract

STUDY DESIGN: To elucidate the pathomechanisms of radicular pain secondary to lumbar disc herniation. OBJECTIVES: To evaluate whether intervertebral disc material applied to the sciatic nerve produces hyperalgesia, and if the hyperalgesia in influenced by inhibitors of phospholipase A2 and nitric ox...

Subject

Sciatic nerve

Hyperalgesia

Medicine

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