Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan

Schosserer, Markus; Minois, Nadege; B. Angerer, Tina; Amring, Manuela; Dellago, Hanna; Harreither, Eva; Calle-Perez, Alfonso; Pircher, Andreas; Peter Gerstl, Matthias; Pfeifenberger, Sigrid; Brandl, Clemens; Sonntagbauer, Markus; Kriegner, Albert; Linder, Angela; Weinhäusel, Andreas; Mohr, Thomas; Steiger, Matthias; Mattanovich, Diethard; Rinnerthaler, Mark; Karl, Thomas; Sharma, Sunny; Entian, Karl-Dieter; Kos, Martin; Breitenbach, Michael; B.H. Wilson, Iain; Polacek, Norbert; Grillari-Voglauer, Regina; Breitenbach-Koller, Lore; Grillari, Johannes

doi:10.1038/ncomms7158

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Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan

Shared by NobleBlocks on Jan 28, 2015 • 12:00 AM UTC

Authors:

Markus Schosserer

Nadege Minois

Tina B. Angerer

Abstract

Abstract Several pathways modulating longevity and stress resistance converge on translation by targeting ribosomal proteins or initiation factors, but whether this involves modifications of ribosomal RNA is unclear. Here, we show that reduced levels of the conserved RNA methyltransferase NSUN5 incr...

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