Schizophrenia and Affective Disorders—Cosegregation with a Translocation at Chromosome 1q42 That Directly Disrupts Brain-Expressed Genes: Clinical and P300 Findings in a Family

Blackwood, Douglas; Fordyce, Alison; T. Walker, Maura; M. St. Clair, David; J. Porteous, David; Muir, Walter

doi:10.1086/321969

Public

Schizophrenia and Affective Disorders—Cosegregation with a Translocation at Chromosome 1q42 That Directly Disrupts Brain-Expressed Genes: Clinical and P300 Findings in a Family

Published in The American Journal of Human Genetics • Aug 1, 2001

Authors:

Douglas Blackwood

Alison Fordyce

Maura T. Walker

Abstract

A family with a (1;11)(q42;q14.3) translocation significantly linked to a clinical phenotype that includes schizophrenia and affective disorders is described. This translocation generates a LOD score of 3.6 when the disease phenotype is restricted to schizophrenia, of 4.5 when the disease phenotype ...

Subject

Chromosomal translocation

Schizophrenia (object-oriented programming)

Genetics

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