Voriconazole versus Amphotericin B for Primary Therapy of Invasive Aspergillosis

Herbrecht, Raoul; W. Denning, David; F. Patterson, Thomas; E. Bennett, John; E. Greene, Reginald; W Oestmann, J; V. Kern, Winfried; A. Marr, Kieren; Ribaud, Patricia; Lortholary, Olivier; Sylvester, Richard; H. Rubin, Robert; R. Wingard, John; Stark, Paul; M. Durand, Christine; Caillot, Denis; Thiel, Eckhard; Chandrasekar, Pranatharthi; R. Hodges, Michael; T. Schlamm, Haran; F. Troke, Peter; de Pauw, Ben

doi:10.1056/nejmoa020191

Public

Voriconazole versus Amphotericin B for Primary Therapy of Invasive Aspergillosis

Published in New England Journal of Medicine • Aug 8, 2002

Authors:

Raoul Herbrecht

David W. Denning

Thomas F. Patterson

Abstract

BACKGROUND: Voriconazole is a broad-spectrum triazole that is active against aspergillus species. We conducted a randomized trial to compare voriconazole with amphotericin B for primary therapy of invasive aspergillosis. METHODS: In this randomized, unblinded trial, patients received either intraven...

Subject

Voriconazole

Medicine

Aspergillosis

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