Once-Daily Valacyclovir to Reduce the Risk of Transmission of Genital Herpes

Corey, Lawrence; Wald, Anna; Patel, Raj; L. Sacks, Stephen; K. Tyring, Stephen; Warren, Terri; M. Douglas, John; Paavonen, Jorma; Ashley Morrow, Rhoda; R. Beutner, Karl; S. Stratchounsky, Leonid; Mertz, Grégory; N. Keene, Oliver; Watson, Helen; Tait, Dereck; Vargas‐Cortes, Mauricio

doi:10.1056/nejmoa035144

Public

Once-Daily Valacyclovir to Reduce the Risk of Transmission of Genital Herpes

Published in New England Journal of Medicine • Dec 31, 2003

Authors:

Lawrence Corey

Anna Wald

Raj Patel

Abstract

BACKGROUND: Nucleoside analogues against herpes simplex virus (HSV) have been shown to suppress shedding of HSV type 2 (HSV-2) on genital mucosal surfaces and may prevent sexual transmission of HSV. METHODS: We followed 1484 immunocompetent, heterosexual, monogamous couples: one with clinically symp...

Subject

Medicine

Placebo

Herpes simplex virus

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