The Ratios of CD8+ T Cells to CD4+CD25+ FOXP3+ and FOXP3- T Cells Correlate with Poor Clinical Outcome in Human Serous Ovarian Cancer

C. Preston, Claudia; J. Maurer, Matthew; L. Oberg, Ann; W. Visscher, Daniel; R. Kalli, Kimberly; C. Hartmann, Lynn; L. Goode, Ellen; L. Knutson, Keith

doi:10.1371/journal.pone.0080063

Public

The Ratios of CD8+ T Cells to CD4+CD25+ FOXP3+ and FOXP3- T Cells Correlate with Poor Clinical Outcome in Human Serous Ovarian Cancer

Published in PLoS ONE • Nov 14, 2013

Authors:

Claudia C. Preston

Matthew J. Maurer

Ann L. Oberg

Abstract

Ovarian cancer is an immune reactive malignancy with a complex immune suppressive network that blunts successful immune eradication. This suppressive microenvironment may be mediated by recruitment or induction of CD4(+) regulatory T cells (Tregs). Our study sought to investigate the association of ...

Subject

FOXP3

Serous ovarian cancer

CD8

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