The ratios of CD8+ T cells to CD4+CD25+ FOXP3+ and FOXP3- T cells correlate with poor clinical outcome in human serous ovarian cancer.

C Preston, Claudia; J Maurer, Matthew; L Oberg, Ann; W Visscher, Daniel; R Kalli, Kimberly; C Hartmann, Lynn; L Goode, Ellen; L Knutson, Keith

doi:10.1371/journal.pone.0080063

Public

The ratios of CD8+ T cells to CD4+CD25+ FOXP3+ and FOXP3- T cells correlate with poor clinical outcome in human serous ovarian cancer.

Shared by NobleBlocks on Jan 1, 2013 • 12:00 AM UTC

Authors:

Claudia C Preston

Matthew J Maurer

Ann L Oberg

Abstract

Ovarian cancer is an immune reactive malignancy with a complex immune suppressive network that blunts successful immune eradication. This suppressive microenvironment may be mediated by recruitment or induction of CD4(+) regulatory T cells (Tregs). Our study sought to investigate the association of ...

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