Recurrent R-spondin fusions in colon cancer

Seshagiri, Somasekar; Stawiski, Eric; Durinck, Steffen; Modrušan, Zora; E. Storm, Elaine; B. Conboy, Caitlin; Chaudhuri, Subhra; Guan, Yinghui; Janakiraman, Vasantharajan; S. Jaiswal, Bijay; Guillory, Joseph; Ha, Connie; J.P. Dijkgraaf, Gerrit; Stinson, Jeremy; Gnad, Florian; A. Huntley, Melanie; D. Degenhardt, Jeremiah; M. Haverty, Peter; Bourgon, Richard; Wang, Weiru; Koeppen, Hartmut; Gentleman, Robert; K. Starr, Timothy; Zhang, Zemin; A. Largaespada, David; D. Wu, Thomas; J. de Sauvage, Frédéric

doi:10.1038/nature11282

Public

Recurrent R-spondin fusions in colon cancer

Published in Nature • Aug 1, 2012

Authors:

Somasekar Seshagiri

Eric Stawiski

Steffen Durinck

Abstract

Exomes, transcriptomes and copy-number alterations in a sample of more than 70 primary human colonic tumours were analysed in an attempt to characterize the genomic landscape; in addition to finding alterations in genes associated with commonly mutated signalling pathways, recurrent gene fusions inv...

Subject

Biology

Wnt signaling pathway

Carcinogenesis

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