HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol

Chung, Wen‐Hung; Chung, Wen‐Hung; Liou, Lieh-Bang; Chu, C.C.; Lin, Marie; Huang, Hsien-Ping; Lin, Yen-Ling; Lan, Joung-Liang; Yang, Li-Cheng; Hong, Hong-shang; Chen, Ming-Jing; Lai, Ping-Chin; Wu, Mai-Szu; Chu, Chia‐Yu; Wang, Kuo-Hsien; Chen, Chien‐Hsiun; S.J. Fann, Cathy; Wu, Jer-Yuarn; Chen, Yuan-Tsong

doi:10.1073/pnas.0409500102

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HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol

Published in Proceedings of the National Academy of Sciences • Mar 2, 2005

Authors:

Wen‐Hung Chung

Lieh-Bang Liou

Abstract

Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent cause of severe cutaneous adverse reactions (SCAR), which include the drug hypersensitivity syndrome, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The adverse events are unpredictable and carry signi...

Subject

Allopurinol

Toxic epidermal necrolysis

Linkage disequilibrium

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