Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor

Tahara‐Hanaoka, Satoko; Shibuya, Kazuko; Kai, Hirayasu; Miyamoto, Akitomo; Morikawa, Yoshihiro; Ohkochi, Nobuhiro; Honda, Shin‐ichiro; Shibuya, Akira

doi:10.1182/blood-2005-04-1684

Public

Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor

Published in Blood • Oct 26, 2005

Authors:

Satoko Tahara‐Hanaoka

Kazuko Shibuya

Hirayasu Kai

Abstract

The poliovirus receptor CD155 and its family member CD112 (nectin-2) are the ligands for the activating cell-surface receptor DNAM-1 on CD8+ T cells and natural killer (NK) cells. Here, we demonstrate that, whereas the RMA tumor grew in syngeneic mice, DNAM-1 ligand-transduced RMA was rejected, in w...

Subject

Receptor

Poliovirus

dNaM

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