HSP70 as Endogenous Stimulus of the Toll/Interleukin-1 Receptor Signal Pathway

Martin Vabulas, R.; Ahmad‐Nejad, Parviz; Ghose, Sanghamitra; J. Kirschning, Carsten; D. Issels, Rolf; Wagner, Hermann

doi:10.1074/jbc.m111204200

Public

HSP70 as Endogenous Stimulus of the Toll/Interleukin-1 Receptor Signal Pathway

Published in Journal of Biological Chemistry • Apr 1, 2002

Authors:

R. Martin Vabulas

Parviz Ahmad‐Nejad

Sanghamitra Ghose

Abstract

Human heat-shock protein (HSP)70 activates innate immune cells and hence requires no additional adjuvants to render bound peptides immunogenic. Here we tested the assumption that endogenous HSP70 activates the Toll/IL-1 receptor signal pathway similar to HSP60 and pathogen-derived molecular patterns...

Subject

Endogeny

Stimulus (psychology)

Receptor

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