Sodium Channel Blockers Identify Risk for Sudden Death in Patients With ST-Segment Elevation and Right Bundle Branch Block but Structurally Normal Hearts

Brugada, Ramón; Brugada, Josép; Antzelevitch, Charles; E. Kirsch, Glenn; Potenza, Domenico; A. Towbin, Jeffrey; Brugada, Pedro

doi:10.1161/01.cir.101.5.510

Public

Sodium Channel Blockers Identify Risk for Sudden Death in Patients With ST-Segment Elevation and Right Bundle Branch Block but Structurally Normal Hearts

Published in Circulation • Feb 8, 2000

Authors:

Ramón Brugada

Josép Brugada

Charles Antzelevitch

Abstract

BACKGROUND: A mutation in the cardiac sodium channel gene (SCN5A) has been described in patients with the syndrome of right bundle branch block, ST-segment elevation in leads V1 to V3, and sudden death (Brugada syndrome). These electrocardiographic manifestations are transient in many patients with ...

Subject

Flecainide

Ajmaline

Medicine

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