Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

M. Walker, Laura; Phogat, Sanjay; Chan-Hui, Po-Ying; Wagner, Denise; Phung, Pham; L. Goss, Julie; Wrin, Terri; Simek, Melissa; P. Fling, Steven; L. Mitcham, Jennifer; Lehrman, Jennifer; Priddy, Frances; Olsen, Ole; M. Frey, Steven; W. Hammond, Phillip; G. Principal Investigators, Protocol; M. Kaminsky, Stephen; J. Zamb, Timothy; Moyle, Matthew; C. Koff, Wayne; Poignard, Pascal; R. Burton, Dennis

doi:10.1126/science.1178746

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Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

Published in Science • Sep 3, 2009

Authors:

Laura M. Walker

Sanjay Phogat

Po-Ying Chan-Hui

Abstract

Broadly neutralizing antibodies (bNAbs), which develop over time in some HIV-1-infected individuals, define critical epitopes for HIV vaccine design. Using a systematic approach, we have examined neutralization breadth in the sera of about 1800 HIV-1-infected individuals, primarily infected with non...

Subject

Virology

Human immunodeficiency virus (HIV)

Antibody

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