Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

Seibert, Karen; Zhang, Y; Leahy, K.; D. Hauser, Scott; L. Masferrer, Jaime; Perkins, W; Lee, L; C. Isakson, Peter

doi:10.1073/pnas.91.25.12013

Public

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

Published in Proceedings of the National Academy of Sciences • Dec 6, 1994

Authors:

Karen Seibert

Y Zhang

K. Leahy

Abstract

Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used for the treatment of inflammatory diseases, but significant side effects such as gastrointestinal erosion and renal damage limit their use. NSAIDs inhibit the enzyme cyclooxygenase (COX), which catalyzes the conversion of arachidonic acid ...

Subject

Cyclooxygenase

Pharmacology

Inflammation

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