PDGF, TGF-β, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages

Ng, Felicia; Boucher, Shayne; Koh, Susie; S. Sastry, Konduru; G. Chase, Lucas; Lakshmipathy, Uma; Choong, Cleo; Yang, Zheng; C. Vemuri, Mohan; S. Rao, Mahendra; Tanavde, Vivek

doi:10.1182/blood-2007-07-103697

Public

PDGF, TGF-β, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages

Published in Blood • Mar 11, 2008

Authors:

Felicia Ng

Shayne Boucher

Susie Koh

Abstract

We compared the transcriptomes of marrow-derived mesenchymal stem cells (MSCs) with differentiated adipocytes, osteocytes, and chondrocytes derived from these MSCs. Using global gene-expression profiling arrays to detect RNA transcripts, we have identified markers that are specific for MSCs and thei...

Subject

Mesenchymal stem cell

Adipogenesis

Cell biology

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