Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARγ: Possible relevance to human fibrotic disorders

Beatriz Frungieri, Mónica; Weidinger, Stephan; Meineke, Viktor; M. Köhn, Frank; Mayerhofer, Artur

doi:10.1073/pnas.232422999

Public

Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARγ: Possible relevance to human fibrotic disorders

Published in Proceedings of the National Academy of Sciences • Oct 23, 2002

Authors:

Mónica Beatriz Frungieri

Stephan Weidinger

Viktor Meineke

Abstract

Mast-cell products can stimulate fibroblast proliferation, implying that these cells are key players in fibrosis. One mast-cell product, the serine protease tryptase, is known to activate protease-activated receptor 2 (PAR2) and cause proliferation of fibroblasts. We found that recombinant tryptase,...

Subject

Tryptase

Prostaglandin D2

Mast cell

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