Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.

C Porter, Donald; Farmaki, Elena; Altilia, Serena; P Schools, Gary; K West, Deborah; Chen, Mengqian; Chang, Bey-Dih; T Puzyrev, Anatoliy; Lim, Chang-uk; Rokow-Kittell, Rebecca; T Friedhoff, Lawrence; G Papavassiliou, Athanasios; Kalurupalle, Swathi; Hurteau, Gregory; Shi, Jun; S Baran, Phil; Gyorffy, Balazs; P Wentland, Mark; V Broude, Eugenia; Kiaris, Hippokratis; B Roninson, Igor

doi:10.1073/pnas.1206906109

Public

Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.

Published in Proceedings of the National Academy of Sciences of the United States of America • Aug 21, 2012

NobleIDark:/48914/w1/20260526/2857F800Record on NobleID

Authors:

Donald C Porter

,

Elena Farmaki

,

Serena Altilia

Abstract

Conventional chemotherapy not only kills tumor cells but also changes gene expression in treatment-damaged tissues, inducing production of multiple tumor-supporting secreted factors. This secretory phenotype was found here to be mediated in part by a damage-inducible cell-cycle inhibitor p21 (CDKN1A...

Discussions