Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status.

S, Schmechel; A, Konrad; J, Diegelmann; J, Glas; M, Wetzke; E, Paschos; P, Lohse; B, Göke; S, Brand

doi:10.1002/ibd.20315

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Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status.

Shared by NobleBlocks on Feb 1, 2008 • 12:00 AM UTC

Authors:

Schmechel S

Konrad A

Diegelmann J

Abstract

Background We analyzed the influence of Crohn's disease (CD)-associated IL23R gene variants on IL-22 that is expressed in IL-23R+ Th17 cells.Methods IL-22 serum levels were measured in 242 CD patients and in 31 healthy controls. Subanalyses included serum levels of IL-6, TNF-alpha, IL-17A, IL-17F, C...

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