Linking genetic susceptibility to Crohnʼs disease with Th17 cell function: IL-22 serum levels are increased in Crohnʼs disease and correlate with disease activity and IL23R genotype status

Schmechel, Silke; Konrad, Astrid; Diegelmann, Julia; Glas, Jürgen; Wetzke, Martin; Paschos, Ekaterini; Lohse, Peter; Göke, Burkhard; Brand, Stephan

doi:10.1002/ibd.20315

Public

Linking genetic susceptibility to Crohnʼs disease with Th17 cell function: IL-22 serum levels are increased in Crohnʼs disease and correlate with disease activity and IL23R genotype status

Published in Inflammatory Bowel Diseases • Nov 16, 2007

Authors:

Silke Schmechel

Astrid Konrad

Julia Diegelmann

Abstract

BACKGROUND: We analyzed the influence of Crohn's disease (CD)-associated IL23R gene variants on IL-22 that is expressed in IL-23R+ Th17 cells. METHODS: IL-22 serum levels were measured in 242 CD patients and in 31 healthy controls. Subanalyses included serum levels of IL-6, TNF-alpha, IL-17A, IL-17F...

Subject

Crohn's disease

Single-nucleotide polymorphism

Genotype

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!