The Effect of Dexrazoxane on Myocardial Injury in Doxorubicin-Treated Children with Acute Lymphoblastic Leukemia

E. Lipshultz, Steven; Rifai, Nader; Dalton, Virginia; E. Levy, Donna; B. Silverman, Lewis; R. Lipsitz, Stuart; D. Colan, Steven; L. Asselin, Barbara; D. Barr, Ronald; A. Clavell, Luis; A. Hurwitz, Craig; Moghrabi, Albert; Samson, Yvan; A. Schorin, Marshall; D. Gelber, Richard; E. Sallan, Stephen

doi:10.1056/nejmoa035153

Public

The Effect of Dexrazoxane on Myocardial Injury in Doxorubicin-Treated Children with Acute Lymphoblastic Leukemia

Published in New England Journal of Medicine • Jul 7, 2004

Authors:

Steven E. Lipshultz

Nader Rifai

Virginia Dalton

Abstract

BACKGROUND: Doxorubicin chemotherapy is very effective in children with acute lymphoblastic leukemia (ALL) but also injures myocardial cells. Dexrazoxane, a free-radical scavenger, may protect the heart from doxorubicin-associated damage. METHODS: To determine whether dexrazoxane decreases doxorubic...

Subject

Dexrazoxane

Doxorubicin

Medicine

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!