Increased Etheno-DNA Adducts in Affected Tissues of Patients Suffering from Crohn’s Disease, Ulcerative Colitis, and Chronic Pancreatitis

Nair, Jagadeesan; Gansauge, Frank; G. Beger, H.; Dolara, Piero; Winde, G; Bartsch, Helmut

doi:10.1089/ars.2006.8.1003

Public

Increased Etheno-DNA Adducts in Affected Tissues of Patients Suffering from Crohn’s Disease, Ulcerative Colitis, and Chronic Pancreatitis

Published in Antioxidants and Redox Signaling • May 1, 2006

Authors:

Jagadeesan Nair

Frank Gansauge

H. G. Beger

Abstract

Chronic inflammatory processes induce oxidative stress and lipid peroxidation (LPO), hereby generating DNA-reactive aldehydes such as trans-4-hydroxy-2-nonenal (HNE). Etheno-modified DNA bases are inter alia generated by reaction of DNA with HNE. Using an immunoaffinity-(32)P-postlabeling method, th...

Subject

Ulcerative colitis

Pancreatitis

Crohn's disease

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