Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study.

K, Schmiegelow; I, Al-Modhwahi; MK, Andersen; M, Behrendtz; E, Forestier; H, Hasle; M, Heyman; J, Kristinsson; J, Nersting; R, Nygaard; AL, Svendsen; K, Vettenranta; R, Weinshilboum

doi:10.1182/blood-2008-11-187880

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Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study.

Shared by NobleBlocks on Feb 17, 2009 • 12:00 AM UTC

Authors:

Schmiegelow K

Al-Modhwahi I

Andersen MK

Abstract

Among 1614 children with acute lymphoblastic leukemia (ALL) treated with the Nordic Society for Paediatric Haematology and Oncology (NOPHO) ALL-92 protocol, 20 patients developed a second malignant neoplasm (SMN) with a cumulative risk of 1.6% at 12 years from the diagnosis of ALL. Nine of the 16 ac...

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