Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria.

GE, Grau; LF, Fajardo; PF, Piguet; B, Allet; PH, Lambert; P, Vassalli

doi:10.1126/science.3306918

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Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria.

Shared by NobleBlocks on Sep 1, 1987 • 12:00 AM UTC

Authors:

Grau GE

Fajardo LF

Piguet PF

Abstract

Tumor necrosis factor, or cachectin (TNF-alpha), a protein with a wide range of biological activities, is produced mainly by macrophages and may be important in inflammatory processes. The role of TNF-alpha in the pathogenesis of cerebral malaria was investigated in a murine model. Most CBA mice inf...

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