Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer’s disease-related pathology

Michaud, Jean-Philippe; Hallé, Maxime; Lampron, Antoine; Thériault, Peter; Préfontaine, Paul; Filali, Mohammed; Tribout-Jover, Pascale; Lanteigne, Anne-Marie; Jodoin, Rachel; W. Cluff, Christopher; Brichard, Vincent; Palmantier, Rémi; Pilorget, Anthony; Larocque, Daniel; Rivest, Serge

doi:10.1073/pnas.1215165110

Public

Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer’s disease-related pathology

Published in Proceedings of the National Academy of Sciences • Jan 15, 2013

Authors:

Jean-Philippe Michaud

Maxime Hallé

Antoine Lampron

Abstract

Alzheimer's disease (AD) is the most common cause of dementia worldwide. The pathogenesis of this neurodegenerative disease, currently without curative treatment, is associated with the accumulation of amyloid β (Aβ) in brain parenchyma and cerebral vasculature. AD patients are unable to clear this ...

Subject

Agonist

Microglia

Toll-like receptor

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