An Immunosurveillance Mechanism Controls Cancer Cell Ploidy

Senovilla, Laura; Vitale, Ilio; Martins, Isabelle; Tailler, Maximilien; Pailleret, Claire; Michaud, Mickaël; Galluzzi, Lorenzo; Adjemian, Sandy; Kepp, Oliver; Niso-Santano, Mireia; Shen, Shensi; Mariño, Guillermo; Criollo, Alfredo; Boilève, Alice; Job, Bastien; Ladoire, Sylvain; Ghiringhelli, François; Sistigu, Antonella; Yamazaki, Takahiro; Rello-Varona, Santiago; Locher, Clara; Poirier-Colame, Vichnou; Talbot, Monique; Valent, Alexander; Berardinelli, Francesco; Antoccia, Antonio; Ciccosanti, Fabiola; Maria Fimia, Gian; Piacentini, Mauro; Fueyo, Antonio; L. Messina, Nicole; Li, Ming; J. Chan, Christopher; Sigl, Verena; Pourcher, Guillaume; Ruckenstuhl, Christoph; Carmona-Gutierrez, Didac; Lazar, Vladimir; M. Penninger, Josef; Madeo, Frank; López-Otín, Carlos; J. Smyth, Mark; Zitvogel, Laurence; Castedo, Maria; Kroemer, Guido

doi:10.1126/science.1224922

Public

An Immunosurveillance Mechanism Controls Cancer Cell Ploidy

Shared by NobleBlocks on Sep 28, 2012 • 12:00 AM UTC

Authors:

Laura Senovilla

Ilio Vitale

Isabelle Martins

Abstract

Keeping Cancer Cells At Bay Cancer cells are often aneuploid; that is, they have an abnormal number of chromosomes. But to what extent this contributes to the tumorigenic phenotype is not clear. Senovilla et al. (p. 1678 ; see the Perspective by Zanetti and Mahadevan ) found that tetraploidization o...

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