Mycobacterium tuberculosis ‐specific CD8 + T cells are functionally and phenotypically different between latent infection and active disease

Rozot, Virginie; Viganó, Selena; Mazza‐Stalder, Jesica; Idrizi, Elita; L. Day, Cheryl; Perreau, Matthieu; Lazor‐Blanchet, Catherine; Petruccioli, Elisa; A. Hanekom, Willem; Goletti, Delia; Bart, Pierre‐Alexandre; Nicod, Laurent; Pantaleo, Giuseppe; Harari, Alexandre

doi:10.1002/eji.201243262

Public

Mycobacterium tuberculosis ‐specific CD8 + T cells are functionally and phenotypically different between latent infection and active disease

Published in European Journal of Immunology • Mar 4, 2013

Authors:

Virginie Rozot

Selena Viganó

Jesica Mazza‐Stalder

Abstract

Protective immunity to Mycobacterium tuberculosis (Mtb) remains poorly understood and the role of Mtb-specific CD8(+) T cells is controversial. Here we performed a broad phenotypic and functional characterization of Mtb-specific CD8(+) T cells in 326 subjects with latent Mtb infection (LTBI) or acti...

Subject

Biology

Mycobacterium tuberculosis

Disease

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